Skip to Main Content

COVID Biobank & Registry

The lack of a biorepository from well-characterized cases with COVID-19 infection and matched controls has been a major barrier in answering questions on the role of host factors that influence disease progression. Yale is therefore creating a tissue repository for research related to emerging respiratory viral infections with particular focus on COVID-19. As part of the Yale COVID-19 Biorepository, researchers at the University are enrolling and prospectively following cohorts of inpatients and outpatients with respiratory symptoms or fever and healthcare workers who are working on COVID-19 units at Yale New Haven Hospital. Specimen collection will support research on factors related to the viral expression, transmission, disease severity, progression, and susceptibility. Through the creation and use of this repository, studies can be undertaken that will provide better understanding of emerging respiratory viral infections including COVID-19. The repository may yield evidence to guide development of new approaches for prevention and control, triaging patients, and novel therapeutics and vaccines in response to the COVID-19 public health emergency. In addition to studying current research questions, these samples will also be stored for future investigations. Thus, the biorepository may provide broad benefits with respect to future public health, biomedical, and translational research initiatives.

Key knowledge gaps that the repository will allow to be addressed in the COVID-19 epidemiology and pathogenesis include:

  • the primary mode of transmission of the disease in the community and amongst the high-risk group of health care workers
  • factors for host susceptibility and resistance
  • the scope of the clinical presentation and outcomes
  • viral and host factors important in lung infections
  • invasion of the central nervous system and other non-respiratory compartments by the virus
  • optimal clinical and laboratory diagnostic approaches for screening and identifying individuals infected with the virus
  • prognostic factors that influence the risk of developing severe clinical outcomes
  • pathogenic mechanisms that influence transmission and development of severe outcomes