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Innovation at Yale

By drawing on the expertise of scientists and engineers across the university, Yale is working to address the challenges created by the COVID-19 pandemic. Faculty are working in close collaboration to devise new approaches that harness Yale’s expertise in areas that range from 3D printing to data science and analytics.

Regulating Pressure to Split Ventilate Two COVID-19 Patients at Once - PReVentS

As hospitals across the country face the possibility of ventilator shortages during the COVID-19 pandemic, researchers at Yale’s Niklasson Lab have designed an elegant workaround. They drew upon previous medical literature about the possibility of using a single ventilator to treat multiple patients in disaster or emergency settings. From those rudimentary designs, they created an entirely new pressure-driven system called the Pressure Regulated Ventilator Splitting response paradigm (PReVentS). This system allows clinicians to individualize the care given to each patient on the ventilator, which is absolutely critical in cases of COVID-19 where patients have varying therapeutic needs over time.

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Combating COVID-19 in the ICU with Dual Ventilation - The Vent Multiplexor

In severe cases of COVID-19 a mechanical ventilator is required to provide oxygen to patients who cannot breathe. Due to the growing number of such cases, hospitals are running short on these much-needed ventilators. Using knowledge gained from  working in the medical intensive care unit, a pulmonary critical care team developed a dual ventilator called the Vent Multiplexor. This device offers individualized emergency crisis care for two adult patients in need of mechanical ventilation using just one ventilator.

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In the United States (US), correctional facilities have been at the center of the COVID-19 pandemic. Prisons and jails are notoriously difficult environments in which to control the spread of infectious diseases due to the lack of sanitary conditions, overcrowding, and the inability to physical distance. Outbreaks within the correctional system have substantial public health repercussions, affecting not only those incarcerated but also those who work in facilities and, by extension, the communities in which jails and prisons sit.

By sequencing the genomes of many cases of SARS-CoV-2, the virus that causes COVID-19, we can learn about how, where, and when it is transmitted.